4-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-6-(but-3-yn­yloxy)pyrimidine

There are two mol­ecules in the asymmetric unit of the title compound, C12H11BrN4O. The dihedral angles between the pyrazole and pyrimidine rings are 1.28 (17) and 1.56 (17)° in the two mol­ecules. In one of the mol­ecules, the but-3-yn­yloxy side chain is disordered over two sets of sites in a 0.714 (8):0.286 (8) ratio

Parallel Acceleration and Improvement of Gravitational Field Optimization Algorithm

The Gravitational Field Algorithm, a modern optimization algorithm, mainly simulates celestial mechanics and is derived from the Solar Nebular Disk Model (SNDM). It simulates the process of planetary formation to search for the optimal solution. Although this optimization algorithm has more advantages than other optimization algorithms in multi-peak optimization problems, it still has the shortcoming of long computation time when dealing with large-scale datasets or solving complex problems. Therefore, it is necessary to improve the efficiency of the Gravitational Field Algorithm (GFA). In this paper, an optimization method based on multi-population parallel is proposed to accelerate the Gravitational Field Algorithm. With the help of the parallel mechanism in MATLAB, the algorithm execution speed will be improved by using the parallel computing mode of multi-core CPU. In addition, this paper also improves the absorption operation strategy. By comparing the experimental results of eight classical unconstrained optimization problems, it is shown that the computational efficiency of this method is improved compared with the original Gravitational Field Algorithm, and the algorithm accuracy has also been slightly improved

Unlock Multi-Modal Capability of Dense Retrieval via Visual Module Plugin

This paper proposes Multi-modAl Retrieval model via Visual modulE pLugin (MARVEL) to learn an embedding space for queries and multi-modal documents to conduct retrieval. MARVEL encodes queries and multi-modal documents with a unified encoder model, which helps to alleviate the modality gap between images and texts. Specifically, we enable the image understanding ability of a well-trained dense retriever, T5-ANCE, by incorporating the image features encoded by the visual module as its inputs. To facilitate the multi-modal retrieval tasks, we build the ClueWeb22-MM dataset based on the ClueWeb22 dataset, which regards anchor texts as queries, and exact the related texts and image documents from anchor linked web pages. Our experiments show that MARVEL significantly outperforms the state-of-the-art methods on the multi-modal retrieval dataset WebQA and ClueWeb22-MM. Our further analyses show that the visual module plugin method is tailored to enable the image understanding ability for an existing dense retrieval model. Besides, we also show that the language model has the ability to extract image semantics from image encoders and adapt the image features in the input space of language models. All codes are available at https://github.com/OpenMatch/MARVEL

The effect of adding a home program to weekly institutional-based therapy for children with undefined developmental delay: A pilot randomized clinical trial

AbstractBackgroundEarly rehabilitation for children with developmental delay without a defined etiology have included home and clinic programs, but no comparisons have been made and efficacy is uncertain. We compared a weekly visit for institutional-based therapy (IT) to IT plus a structured home activity program (HAP).MethodsSeventy children who were diagnosed with motor or global developmental delay (ages 6-48 months and mean developmental age 12.5 months) without defined etiology were recruited (including 45 males and 23 females). The outcomes included the comprehensive developmental inventory for infants and toddlers test and the pediatric evaluation of disability inventory.ResultsChildren who received only IT improved in developmental level by 2.11 months compared with 3.11 months for those who received a combination of IT and HAP (p = 0.000). On all domains of the comprehensive developmental inventory for infants and toddlers test, except for self-help, children who participated in HAP showed greater improvements, including in cognition (p = 0.015), language (p = 0.010), motor (p = 0.000), and social (p = 0.038) domains. Except on the subdomain of self-care with caregiver assistance, the HAP group showed greater improvement in all the pediatric evaluation of disability inventory subdomains (p < 0.05).ConclusionEarly intervention programs are helpful for these children, and the addition of structured home activity programs may augment the effects on developmental progression

EVH Black Holes, AdS3 Throats and EVH/CFT Proposal

Within class of generic black holes there are extremal black holes (with vanishing Hawking temperature T) and vanishing horizon area Ah, but with finite Ah/T ratio,the Extremal Vanishing Horizon (EVH) black holes. We study the near horizon limit of a four dimensional EVH black hole solution to a generic (gauged) Einstein-Maxwell dilaton theory and show that in the near horizon limit they develop a throat which is a pinching orbifold limit of AdS3. This is an extension of the well known result for extremal black holes the near horizon limit of which contains an AdS2 throat. We show that in the near EVH near horizon limit the pinching AdS3 factor turns to a pinching BTZ black hole and that this near horizon limit is indeed a decoupling limit. We argue that the pinching AdS3 or BTZ orbifold is resolved if the near horizon limit is accompanied by taking the 4d Newton constant G4 to zero such that the Bekenstein-Hawking entropy S = Ah/(4G4) remains finite. We propose that in this limit the near horizon EVH black hole is dual to a 2d CFT. We provide pieces of evidence in support of the EVH/CFT correspondence and comment on its connection to the Kerr/CFT proposal and speculations how the EVH/CFT may be used to study generic e.g. Schwarzchild-type black holes.Comment: 31 pages, 3 figures, JHEP styl

CO2 Hydrogenation on Metal-Organic Frameworks-Based Catalysts: A Mini Review

Conversion of carbon dioxide (CO2) into value-added fuels and chemicals can not only reduce the emission amount of CO2 in the atmosphere and alleviate the greenhouse effect but also realize carbon recycling. Through hydrogenation with renewable hydrogen (H2), CO2 can be transformed into various hydrocarbons and oxygenates, including methanol, ethanol, methane and light olefins, etc. Recently, metal-organic frameworks (MOFs) have attracted extensive attention in the fields of adsorption, gas separation, and catalysis due to their high surface area, abundant metal sites, and tunable metal-support interface interaction. In CO2 hydrogenation, MOFs are regarded as important supports or sacrificed precursors for the preparation of high-efficient catalysts, which can uniformly disperse metal nanoparticles (NPs) and enhance the interaction between metal and support to prevent sintering and aggregation of active metal species. This work summarizes the recent process on hydrogenation of CO2 to methanol, methane and other C2+ products over various MOFs-based catalysts, and it will provide some dues for the design of MOFs materials in energy-efficient conversion and utilization

Genomic insight into diet adaptation in the biological control agent Cryptolaemus montrouzieri

Background: The ladybird beetle Cryptolaemus montrouzieri Mulsant, 1853 (Coleoptera, Coccinellidae) is used worldwide as a biological control agent. It is a predator of various mealybug pests, but it also feeds on alternative prey and can be reared on artificial diets. Relatively little is known about the underlying genetic adaptations of its feeding habits. Results: We report the first high-quality genome sequence for C. montrouzieri. We found that the gene families encoding chemosensors and digestive and detoxifying enzymes among others were significantly expanded or contracted in C. montrouzieri in comparison to published genomes of other beetles. Comparisons of diet-specific larval development, survival and transcriptome profiling demonstrated that differentially expressed genes on unnatural diets as compared to natural prey were enriched in pathways of nutrient metabolism, indicating that the lower performance on the tested diets was caused by nutritional deficiencies. Remarkably, the C. montrouzieri genome also showed a significant expansion in an immune effector gene family. Some of the immune effector genes were dramatically downregulated when larvae were fed unnatural diets. Conclusion: We suggest that the evolution of genes related to chemosensing, digestion, and detoxification but also immunity might be associated with diet adaptation of an insect predator. These findings help explain why this predatory ladybird has become a successful biological control agent and will enable the optimization of its mass rearing and use in biological control programs